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Everything known comes from animal models and cell cultures

Microbiology 143 , 21792187 (1997)

Harsh chemicals like hydroquinone, which have been used historically for skin lightening, can cause side effects such as skin irritation, ochronosis (a bluish-black discoloration), and even increased risk of cancer with prolonged use

Studies exploring vascular pathways suggest that peptide signaling can influence endothelial function and blood vessel formation

Katsch, H

Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition)