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In certain cases, it was found that MBP attains natively folded state and remains soluble while the passenger proteins could not attained properly folded state and exist as in the state of soluble aggregates (Nallamsetty et al

Journal of Aging Science , 4(1), 166

Consistent with this finding, upregulation of Cx43 hemichannels was observed in an AD mouse model (Mei et al., 2010), and AD patients displayed higher levels of ATP in brain regions surrounding -amyloid plaques (Mecheri et al., 1997