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If the mutation occurs in the R702W gene, the NF-B signaling pathway is unregulated, which protects the body from the damage of oxidative stress induced by HP (Poplawski et al., 2013)

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Its worth noting that AOD-9604 was very well tolerated in trials, with no major safety issues reported

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Actigraphy: Around-the-clock activity and resting states are registered in the home environment for a longer period of time, thus enabling an estimation of total sleep time, sleep efficiency, sleep latency and sleep fragmentation, as well as screening for circadian rhythm disorders