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Notably, the three-dimensional structure indicates that OsDHAR contains a broad, uncharged cleft between the 2-helix and the 3-helix as the putative binding site for non-native protein folding intermediates for its chaperone-like activity

If you add the same 2ml of bacteriostatic water, you get a concentration of 5mg/ml instead of 2.5mg/ml

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Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure

Prior art literature such as United States Patents US4797284 and US4880633 had employed propylene glycol as a penetration enhancer which is gelled with 2 percent hydroxypropyl guar (HP-60 Jaguar from Celanese) which served as a dissolved drug reservoir