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The first to report on the development of PROTACs, marking a major innovation in the field by introducing chimeric molecules designed to induce targeted protein degradation through the Skp1CullinF box complex

Thyroid storm management: Beta-blockers (e.g., propranolol) to manage tachycardia and block T4 to T3 conversion

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16, 2008 A research team supported by the National Institutes of Health (NIH) Roadmap and the National Institute of Allergy and Infectious Diseases (NIAID) has identified chemical compounds that hold promise as potential therapies for schistosomiasis, a parasitic disease that afflicts more than 200 million people worldwide

The event rate was so low that it was impossible to estimate the risk