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Feature · Product Review

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB dbco-maleimide In click chemistry

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB dbco-maleimide In click chemistrySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine

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Description

In click chemistry

where PC-6 is converted into a positively charged product (PAD6) upon incorporation into NAD

and Escherichia coli dihydrofolate reductase (eDHFR)

The activities of SNAP-tag and H5 enzymes on BGSN3 are reasonable (IC50=17

1038/nchem

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB dbco-maleimide In click chemistrySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine

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