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Clinical challenges and mitigation strategies Core clinical and research challenges With the widespread clinical use of platinum-based chemotherapeutics, long-term in vivo platinum accumulation has emerged as a critical yet underrecognized clinical challenge, serving as the core toxicological driver of impaired long-term quality of life and adverse health outcomes in cancer survivors

Chen Z, Yang B, Yan Z, Song E, Song Y

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Experimentally, GPX4-knockout mice demonstrate that inactivation of this key ferroptosis-regulating enzyme triggers neuronal loss accompanied by lipid peroxidationa phenotype attenuated by ferroptosis inhibitors such as liproxstatin-1

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