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However, sensitivity analysis indicated adequate power to detect moderate-to-large between-group effects, whereas small effect sizes may have remained undetected

L-Glutathione (GSH), especially in nanoparticle slow-release form, maintains redox tone but excessive co-delivery creates a reductive stress, paradoxically inactivating Nrf2, SIRT3, and AMPK, the very genes responsible for antioxidant renewal

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Abstract Nuclear factor erythroid 2related factor 2 (Nrf2) is a key transcription factor that regulates the expression of genes involved in cellular protection against oxidative stress and the maintenance of redox homeostasis

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