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Intravital imaging To test if ABT treatment influences OTA transport kinetics, intravital imaging of OTA transport in the livers of mice pre-treated with PBS or ABT was performed using a two-photon microscope (LSM MP7, Zeiss, Germany), as previously described (Hassan 2016

Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

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One possible explanation is that microglia possess specific mechanisms to sense intracellular lactate concentrations

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