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lower left panel: blood vessels of heart tissue were shown, scale bar: 50 m) from various organ-specific Aldh2 KO mice listed in Table (a), representative of two independent experiments

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2.4 Mediation of targeted therapy resistance Under the pressure of the selection of targeted drugs, tumor cells evade treatment through metabolic reprogramming ( Notably, this metabolic adaptation often coexists with and may be reinforced by the reactivation of oncogenic signaling pathways, which provide complementary survival signals under therapeutic pressure

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doi: 10.1038/nrm3270 61 KaraskovEet al

Liver health: The liver is the primary organ responsible for producing and regulating glutathione levels