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Classical homocystinuria has been recognised as a protein misfolding disorder as many of the known pathogenic mutations result in aggregation and degradation of the CBS enzyme 9,10

Subsequently, exported iron is oxidised by ceruloplasmin to Fe3+ and binds to transferrin (Tf) [49]

Recent findings indicate that BCP alleviates oxidative stress, inflammation, and apoptosis, demonstrating a protective effect against doxorubicin-induced cardiotoxicity (Meeran et al., 2019)

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(Wilmington, MA, USA) were maintained and bred at the animal house of the Fondazione IRCCS Carlo Besta Neurological Institute, in compliance with institutional guidelines and international regulations (EEC Council Directive 86/609)

doi: 10.1186/s13073-016-0299-7