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Inversely, perturbation of mitochondrial dynamics produces profound and pleiotropic epigenomic consequences: conditional deletion of the fission factor Drp1 in oocytes causes peri- and post-implantation failure accompanied by transcriptional and proteomic dysregulation, disorganization of the subcortical maternal complex, and reduced DNA methylation and H3K27me3 levels [78]

Science 1984, 226: 10971099

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The treatment reverted impaired insulin signaling manifested by a decrease in phosphorylation of insulin receptor, Akt and GSK3 in both cell types

This allows cysteine oxidation data to be normalized to protein expression data to correct for changes in protein turnover (Parker et al., 2015)