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NRF2 coordinates with several antioxidant pathways in response to oxidative stress (Figure 2)

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Additionally, O 2 may reduce ferric iron (Fe 3+ ) to ferrous iron (Fe 2+ ) in ironsulfur centers in critical proteins, which may lead to enzyme inactivation and concomitant loss of Fe 2+ from the enzymes, thereby promoting production of H 2 O 2 ( 2 O 2 may then react with Fe 2+ to produce hydroxy radicals (OH ) via the Fenton/HaberWeiss reaction

BioMed Pharmacother (2006) 60(3):97108

Patil et al., 2024

This shift toward personalized microbiome-targeted interventions represents the envisioned future trajectory of probiotic science and therapeutic development (536)