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It is involved in cell adhesion, proliferation, migration, and angiogenesis ( in-vitro matured mouse cumulus-oocyte complexes mice injected with HCG resulted in significantly down-regulated transcription and translation of the versican gene in follicles ( in vitro mouse oocyte maturation, cumulus-specific genes like PTGS2, TNFAIP6, and HAS2 become more significant ( The variance in all these genes expression is possibly due to different materials and methods used in the studies

Citrulline is generally well-tolerated with fewer gastrointestinal side effects than arginine

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Proper monitoring ensures that treatment remains within safe physiological limits

Neither is FDA-approved

These gaps highlight the need for future research to move beyond single-cell type and descriptive mechanisms toward systematic dissection of intercellular crosstalk, renal parenchymal cell contributions, and clinical validation