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This control is crucial for regenerative medicine applications, particularly in repairing bone, cartilage, or soft tissues, such as in the treatment of osteoarthritis

[PubMed] [Google Scholar] Huang C, Chang L, Anderson ME, Meister A

Because of this, side effects are expected to some degree

Furthermore, the PDS sequence should remain relatively constrained between plant species (as it exists in all varieties) allowing us to draw from experiments done in other model systems

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Although less severe, the osteocyte-specific igf-1 knockouts showed a significant reduction in growth plate length that was attributed to the decrease in the length of the hypertrophic zone with no abnormalities in the proliferative zone ( Table 1 provides a summary of skeletal phenotypes of the various igf-1 and igf-1r knockouts of relevance to bone