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Tauopathy Tau pathology is another major hallmark of AD that is defined by the accumulation of hyperphosphorylated tau protein in neurons, which progress to form intracellular aggregates termed neurofibrillary tangles (NFTs)

Guan Y, Peiffer B, Feng D, Parra M.A., Wang Y., Fu Y., et al

Moreover, designing standard methods to isolate and identify the types and sources of exosomes also needs to be investigated more since the purity and physicochemical properties of exosomes are strongly affected by their isolation method, and no globally accepted standard is currently available in this era

After the washing step, TMB substrate was added and kept at 37 C or 10 min in the dark to allow the color to develop

For this study, researchers found the tests to be as accurate as lab-based OGTTs when used in adults with glucose intolerance, type 2 diabetes, or in pregnant women to diagnose gestational diabetes

Similar to the IBD and EAE models discussed above, helminthic therapy in the NOD mouse also triggers Th2 skewing due to increases in IL-4 and IL-13 expression, ameliorating Th1-mediated disease (Table 1)