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Relating back to osteoarthritic progression, ROS assumes a pivotal role in its pathogenesis since it becomes partially responsible for cartilage destruction and chronic inflammation

2002 May;56(5):655-69

Among them, enteric glial cells (EGCs) are the main cells of the enteric nervous system, which is associated with the inflammatory response

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GHK-Cu downregulates acute-phase and pro-inflammatory cytokines (TNF-?, IL-6), upregulates anti-oxidant defenses (including superoxide dismutase, Nrf2 and HO-1 pathways), and suppresses fibrotic signaling by inhibiting TGF-?1/Smad2/3 activation