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Blood platelets express a blood clotting, vessel-constricting compound called thromboxane A2 or TXA2, which is synthesized by COX-1

FDA prescribing information for Mounjaro (tirzepatide) , the official label containing approved dosing, contraindications, and clinical trial data

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Xiang Y, Xiaoshan Z, Li W, Zhang R, Xingxiang P, Shuhong W, Lei L, Tong P, Wang J, Qinghe M, Luc G, Minna J, Roth JA, Swisher SG , Heymach JV, Bingliang F

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HbS carriers have lower pathogen loads following malaria infection, potentially resulting in reduced antigenic stimulation and a weaker immune response, rather than direct modulation of the immune system by HbS