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Each shows a very clear rise and fall over the late 20th century

Mitochondria play an important role in multiple cellular senescence mechanisms (van Deursen, 2014), and in senescent cells we can observe changes in mitochondria, including morphological changes such as increase in size, loss of mitochondrial cristae, and accumulation of mitochondrial ROS, with mutations in mtDNA, collectively known as senescence-associated mitochondrial dysfunction (SAMD)

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He lost an estimated $8,000 in sales, damaged relationships with customers who could not complete purchases, and spent countless hours dealing with the crisis