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Liao T, Mei W, Zhang L, Ding L, Yang N, Wang P, et al

[8] Chemotherapy-induced peripheral neuropathy (CIPN): A review of two studies concluded that ALC may be a treatment option for paclitaxel- and cisplatin-induced CIPN, while a clinical trial showed it did not prevent CIPN and appeared to worsen the conditions in taxane therapy

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Conversely, TMAO can release inflammatory factors (caspase-1, IL-1 ) (49) in a dose-and time-dependent manner by activating the reactive oxygen species (ROS)thioredoxin-interacting protein (TXNIP) NLRP3 signaling pathway (50) and inhibiting sirtun3 (SIRT3) superoxide dismutase2 (SOD2)mitochondrial ROS signaling pathway (51), thereby causing endothelial cell injury and aggravating the formation and development of atherosclerosis

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