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p16 ink4a is a cyclin-dependent kinase inhibitor that activates retinoblastoma-associated protein and induces cellular senescence [64], while the loss of nuclear HMGB-1 is considered a senescence biomarker [16, 44]

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At present, there is a lack of evidence on whether high intake of vitamin K has an adverse effect on patients with pulmonary fibrosis

Compounds10p combines the induction of both ferroptosis and autophagy, making it a potential candidate for the treatment of CRC [134]

In normal individuals, a severe deficiency of thiamine (VitaminB1)will produce beriberi, a disease of diffuse symptoms associated with decreased activity of the 3 thiamine-dependent enzymes (pyruvate dehydrogenase, -ketoglutarate dehydrogenase, and transketolase)