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In conclusion, mitochondrial OXPHOS is upregulated in glioblastoma upon glucose starvation

13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells

Abstract P4-12-17: Pre-clinical data and phase I design for PQ-203: a novel peptide-drug conjugate (PDC) targeting the SORT1 receptor in hormone receptor Triple Negative Breast Cancer (TNBC)

113,114 In MASLD and MASH, E3 ligases play dual roles, with both protective and pathological implications

In more detail, nineteen studies deal with AD or MCI [16,20,23,29,36,39,40,41,42,43,44,45,46,47,48,49,50,51,52], three with vascular cognitive impairment (VCI) [53,54,55], five with HE [56,57,58,59,60], four with other secondary dementias [61,62,63,64], and six with an unspecified cognitive disorder [65,66,67,68,69,70]

Because clinical studies directly targeting the amino acid metabolism-macrophage axis in autoimmune diseases remain limited, some translational evidence at the current stage is still derived mainly from pharmacological studies of the same targets in tumors or broader inflammatory diseases