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Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain

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Athira Pharma's fosgonimeton (ATH-1017) targets the same HGF/c-Met program but is structurally distinct (sources conflict on whether it is a prodrug of Dihexa or a separate molecule)