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In health cells, cytosolic NADH is shuttled into mitochondria, where it is turned into NAD + by OXPHOS whereas in cancer cells, the conversion of NAD + to NADH in mitochondria is not sufficient for the high rate of glycolysis due to reduced OXPHOS

In the subgroup analysis by exercise duration, only exercise lasting 8 weeks or less significantly improved GPX activity (SMD = 0.54

Under OS, HIF-1 is stabilized via nitrogen oxide (NOX)/ROS, which upregulates glycolytic enzymes (SLC2A1 and HK) and inhibits mitochondrial respiration via PDK1 activation [222]

In vivo infection experiments demonstrated that Klra17 -/- mice showed augmented splenomegaly and increased titers of S

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Mutants lacking mavL or lnaB were constructed using strain Lp02 as previously described 42