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Its high prevalence during the reproductive years and rapid increase during pregnancy fully confirm the central regulatory role of estrogen and progesterone [13]

Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells

promote the proliferation of granulosa cells by reducing the apoptosis process leading to cell death support the oocyte maturation that was impaired in this mice model promote the synthesis of sex steroid hormones Other in-vivo studies have demonstrated the benefits of curcumin in supporting follicle development and steroidogenesis (64-66)

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In NAFLD patients, this diet-mediated ACLY induction occurs mainly through SREBP-1c 51,88 , but a recent mouse study showed that ChREBP is also responsible for fructose-induced expression of ACLY and other glycolytic, fructolytic, and lipogenic genes 89