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Zonal organization: Articular cartilage has superficial zone (tangential collagen orientation, highest cell density), middle zone (random collagen orientation, largest proteoglycans), deep zone (perpendicular collagen orientation, calcified interface with bone), and tidemark (boundary between calcified and uncalcified cartilage)

The temperature difference between refrigerated solution and body tissue creates a localized reaction that manifests as stinging or burning

After reconstitution: Store at 28C and use within 1428 days

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It is not FDA-approved for the treatment, prevention, or cure of any disease

Only a healthcare professional should administer the injection